小猪视频

Background

Dr. Abiche Dewilde is passionate about finding novel methods to combat cancer. In addition to her years of experience in biomedical devices, cancer biology, cell biology, drug research, clinical trials and animal research, Dr. Dewilde has extensive experience with multiple aspects of cell and animal-based drug discovery and development.

Dr. Dewilde is the founder and Chief Scientific Officer of InVitroMetrix, which created a self-contained, cell-based multi-well research device for drug discovery. InVitroMetrix was spawned from Dr. Dewilde鈥檚 postdoctoral fellowship, where she refined a multi-well cell-based QCM Biosensor for phenotypic cell drug discovery, toxicity testing, and cancer diagnosis, a technology that was subsequently patented.

Dr. Dewilde conducted research on multiple grants on tissue and limb regeneration, extracellular matrix isolation, cancer treatment using Nano particle conjugated targeted therapies, nano-toxicology research, and cancer toxicology research using the Quartz Crystal Microbalance (QCM).

Degrees

• BS in Biotechnology from Worcester Polytechnic Institute
• MS in Biology from the University of Massachusetts Lowell
• Ph.D. in Biomedical engineering and Biotechnology from the University of Massachusetts Lowell

Specialties

Biomedical Devices
Cancer Biology
Cell Biology
Developmental Biology
Regenerative medicine
Immunology

Courses Taught

Biol-404 Developmental Biology
Biol-404L Developmental Biology Lab
Biol-350 Environmental and Applied Microbiology
Biol-350L Environmental and Applied Microbiology Lab
Biol-106 Anatomy and Physiology II
Biol-106L Anatomy and Physiology II Lab
Biol-105L Anatomy and Physiology I Lab
Biol-103 General Biology
Biol-103L General Biology Lab

Recent Publications, Grants and Proceedings

• Using Arduinos to Transition a Bioinstrumentation Lab to Remote Learning. Dewilde AH, Li Y. Biomed Eng Educ. 2021;1(2):313-316. doi: 10.1007/s43683-020-00042-9. Epub 2020 Nov 30. PMID: 35178537
• Quartz crystal microbalance measurements of mitochondrial depolarization predicting chemically induced toxicity of vascular cells and macrophages. Dewilde AH, Wang G, Zhang J, Marx KA, Therrien JM, Braunhut SJ. Anal Biochem. 2013 Aug 1;439(1):50-61. doi: 10.1016/j.ab.2013.04.002. Epub 2013 Apr 11. PMID: 23583820
• Understanding and correcting for carbon nanotube interferences with a commercial LDH cytotoxicity assay. Wang G, Zhang J, Dewilde AH, Pal AK, Bello D, Therrien JM, Braunhut SJ, Marx KA. Toxicology. 2012 Sep 28;299(2-3):99-111. doi: 10.1016/j.tox.2012.05.012. Epub 2012 May 23. PMID: 22634321
• Dynamic cell adhesion and viscoelastic signatures distinguish normal from malignant human mammary cells using quartz crystal microbalance. Zhou T, Marx KA, Dewilde AH, McIntosh D, Braunhut SJ. Anal Biochem. 2012 Feb 1;421(1):164-71. doi: 10.1016/j.ab.2011.10.052. Epub 2011 Nov 7. PMID: 22119070
• A living cell quartz crystal microbalance biosensor for continuous monitoring of cytotoxic responses of macrophages to single-walled carbon nanotubes. Wang G, Dewilde AH, Zhang J, Pal A, Vashist M, Bello D, Marx KA, Braunhut SJ, Therrien JM. Part Fibre Toxicol. 2011 Jan 25;8:4. doi: 10.1186/1743-8977-8-4. PMID: 21266033
• Herceptin-directed nanoparticles activated by an alternating magnetic field selectively kill HER-2 positive human breast cells in vitro via hyperthermia. Zhang J, Dewilde AH, Chinn P, Foreman A, Barry S, Kanne D, Braunhut SJ. Int J Hyperthermia. 2011;27(7):682-97. doi: 10.3109/02656736.2011.609863. PMID: 21992561
• BioDome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration. Hechavarria D, Dewilde A, Braunhut S, Levin M, Kaplan DL. Med Eng Phys. 2010 Nov;32(9):1065-73. doi: 10.1016/j.medengphy.2010.07.010. Epub 2010 Aug 13. PMID: 20708956
• Extracellular matrix-derived products modulate endothelial and progenitor cell migration and proliferation in vitro and stimulate regenerative healing in vivo. Vorotnikova E, McIntosh D, Dewilde A, Zhang J, Reing JE, Zhang L, Cordero K, Bedelbaeva K, Gourevitch D, Heber-Katz E, Badylak SF, Braunhut SJ. Matrix Biol. 2010 Oct;29(8):690-700. doi: 10.1016/j.matbio.2010.08.007. Epub 2010 Aug 24. PMID: 20797438
• Degradation products of extracellular matrix affect cell migration and proliferation. Reing JE, Zhang L, Myers-Irvin J, Cordero KE, Freytes DO, Heber-Katz E, Bedelbaeva K, McIntosh D, Dewilde A, Braunhut SJ, Badylak SF. Tissue Eng Part A. 2009 Mar;15(3):605-14. doi: 10.1089/ten.tea.2007.0425. PMID: 18652541